The flexibility evaluation has four different options to choose from. Depending on the situation, the user might require one or multiple methods for computationally assessing the flexibility, Anisotropic Network Model (ANM), and Gaussian Network Model (GNM). At the same time, the user may use the information already present in the PDB file (as the B-factor value) and/or upload a file with their own calculated b-factors, from Molecular Dynamics’ simulations, for example. If more than one flexibility evaluation method is used, the correlation in between different methods is shown after the evaluations are done.