This last step completes the loop grafting pipeline by replacing the selected scaffold loops by the insert loops. All possible insertion points along the two flanking regular structures of the selected loops that would produce different grafted protein sequences are considered. The total number of solutions to be explored is limited at 1000, so we recommend to explore a short number of loops. At this point, number of possible solutions from the grafted proteins are displayed, and the user can download the solutions and/or start modelling. The user should be able to display and retrieve the results in the form of multiple possible grafted protein arrangements. The 3D structure of each of the grafted designs is built and evaluated by the MODELLER tool for homology modelling and their side-chains conformation is further optimized and the models re-evaluated by Rosetta FastRelax. These later tasks will be performed and displayed depending on the initial license agreement by the user.